Bremelanotide (PT-141): Tell Me More
What is Bremelanotide?
Bremelanotide, also known as PT-141 or PT141, is a research peptide. Sometimes referred to as the Libido Drug, its effects were first identified by Dr. Norman Levine when researching Melanotan 2. Currently, Bremelanotide is being studied for its efficacy in treating Sexual Desire Disorder and Sexual Arousal Disorder in both male and female test subjects. Current clinical trials are primarily focused on female use cases, but numerous studies and tests indicate that mechanism for arousal works in men as well.
For men with Erectile Dysfunction or Low Libido (hypoactive sexual arousal disorder), this peptide increases desire. Unlike Cialis or Viagra, it stimulates erections by opening up the receptors associated with increased sexual desire. Cialis and Viagra function on a mechanical level, affecting the vascular system and increasing the flow of blood throughout the body.
How was it Discovered?
During Melanotan II testing for melanoma prevention, spontaneous erections were identified in one of the test subjects. Testing was then conducted on 10 men with a history of erectile dysfunction. The doctors alternated the dosing between Melanotan 2 and a placebo. Nine of the ten men developed erections when given the real drug. Once the correlation was identified, it was a matter of identifying cause. Further research and testing isolated the source to what we now call PT-141.
Does Bremelanotide Work?
The short answer is YES. According to a double-blind study that Palatin performed on female subjects “… bremelanotide self-administered at home at 1.25 and 1.75 mg SC (subcutaneous) was effective in decreasing distress, increasing arousal and desire, and increasing the number of SSEs (sexually satisfying events), with robust dose response and consistency of effect across all key endpoints. Efficacy was seen in both HSDD (hypoactive sexual desire disorder) and mixed HSDD/FSAD (female sexual arousal disorder) populations.These improvements continued throughout the treatment period, indicating that patients may be able to continue improving after 3 months of treatment.”
For a non-scientific study, Men’s Journal has a slightly more interesting article on one man’s journey once he found where to buy Bremelanotide.
Mechanism of Bremelanotide
From PubMed.gov: “Melanocortins affect multiple physiological responses, including sexual behaviors. Bremelanotide is a synthetic peptide melanocortin analog of alpha-melanocyte-stimulating hormone that is an agonist at melanocortin receptors MC3R and MC4R.”
Basically, bremelanotide activates melanocortin receptors. The receptors are responsible for regulating the desire for sex and procreation. As a result, subjects find a strong increase in desire to mate. Animal testing results have shown significant increases in lordosis behavior. This is when a female animal positions for mating by lowering its front end and increases the ease of copulation.
Bremelanotide Side Effects
Palatin provides a list of side effects from their extensive testing:
- facial flushing
- increased blood pressure
Women (generally more mild)
- nasal congestion
Where to Buy Bremelanotide
Here at Optimum Peptides, we sell only the highest quality peptides. All of our peptides are manufactured in an ISO compliant laboratory setting. Our technicians are trained and certified. All of our products are Made in the USA Peptides. Check them out here.
As always, our Peptides are for research purposes only and not intended for human consumption.